Separations for Proteins and Large Biological Molecules
Large Molecule LC (Bio LC)
The separation of active ingredients that have been manufactured using biological processes often requires a different approach.
Ion exchange separates on the basis of charge on the molecule. It is used often for the separation of peptides, proteins and oligonucleotides
A 300Å pore size with a C4 or C8 phase is suitable for small proteins and large peptides. Proteins are retained by adsorbtion of the hydrophobic foot